![]() Following a single intranasal OT (24 IU) or placebo administration, neural responses were investigated using a monetary reward task. Twenty-four male children and adolescents with RAD (10–18 years old) and 27 age- and sex-matched typically developing individuals (10–17 years old) were included in this randomized, double-blind, placebo-controlled, cross-over, functional magnetic resonance imaging study. We investigated whether single-use intranasal OT administration improved neural responses during reward processing in patients with RAD compared with healthy controls. Oxytocin (OT) administration is known to promote reward functioning. Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain therefore, pharmacological interventions to aid and boost treatment responses are needed. Reactive attachment disorder (RAD) is associated with socially and emotionally withdrawn/inhibited behaviors and reduced neural responses to rewards. 3Research Center for Child Mental Development, University of Fukui, Fukui, Japan. ![]() ![]() 2Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, Japan.1Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan.Fujisawa 2,3, Shota Nishitani 2,3 and Akemi Tomoda 1,2,3* Shinichiro Takiguchi 1,2, Kai Makita 3, Takashi X.
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